There's two quests zones I found out that you can't enter if your high level. Caergate (20-29) and Viledon (30-39)
This quick quest guide helps if your over level 40 and want those main quests done in Nemesis
As stated there, the two PVP zones hold nothing special for any quests there.
EDIT: There is a Nemesis V2 without autopath if you need the quests there