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Depends. Damage calculations run only once - when the first tick of damage hits. If the debuff expires before that, it won't have any effect. If it disappears after that, it will take full effect. Multiple damage hits are purely for animation, they're not evaluated separately. Note how for each such skill, all damage hits do exactly the same damage *, and they either all miss, all hit or all crit. Or if you get stunned halfway through the animation, the remaining damage still applies (especially noticeable on large WH AoEs or many mech skills). * actually the last hit will do slightly more or less due to rounding, e.g. an attack that does 100 damage in 3 hits will do 33/33/34 or 34/34/32.